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Studies in rodents and primates have shown that bupropion exhibits some pharmacologic actions common to psychostimulantsIn rodentsit has been shown to increase locomotor activityelicit a mild stereotyped behavioral responseand increase rates of responding in several schedule-controlled behavior paradigmsIn primate models to assess the positive reinforcing effects of psychoactive drugsbupropion was self-administered intravenouslyIn ratsbupropion produced amphetamine-like and cocaine-like discriminative stimulus effects in drug discrimination paradigms used to characterize the subjective effects of psychoactive drugs.

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MusculoskeletalInfrequent were leg crampsAlso observed were muscle rigidity/fever/rhabdomyolysis and muscle weakness.

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