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Closer monitoring of patients with hypothyroidism co-administered with sevelamer hydrochloride and levothyroxine is recommendedsee section 4.5

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Because these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to estimate their frequency or to establish a causal relationship to drug exposure.

Patients with long-term kidney disease cannot eliminate phosphate from their bodiesThis leads to hyperphosphataemiawhichin the long termcan cause complications such as heart and bone diseaseThe active substance in Renagelsevelamer hydrochlorideis a phosphate binderWhen taken with mealsit attaches to phosphate from food within the gutpreventing it from being absorbed into the bodyThis helps to reduce the phosphate levels in the blood.

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