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Frequency not reportedEczematouspruritic rasherythema multiformeStevens-Johnson syndrometoxic epidermal necrolysisphotosensitivitypurpuraalopeciaRef]

Simvastatin has been associated with rare cases of severe myopathy and rhabdomyolysisThis is accompanied by elevations in creatine kinasemyoglobinuriaand proteinuriaas well as renal failureExperience with HMG-CoA reductase inhibitors indicates that concomitant use with gemfibrozilnicotinic acidcyclosporinor erythromycin may increase the incidence and the severity of musculoskeletal side effects.

Muscle breakdown is also a serious problemIf statins cause the muscle protein myoglobin to leech into the bloodstreamit can shut down the kidneyswhich aren’t equipped to filter out that proteinThat condition is called rhabdomyolysisand can be potentially fatal.

High cholesterol can be a dangerous conditionTake the Cholesterol Quiz to understand what high cholesterol means in terms of.

Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effectsDo not consume grapefruit products while taking this medication.

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